UTHSC Molecular Resource Center
The MRC’s mission is to provide the scientists at the UTHSC and other UT campuses with access to the latest technologies for exploring the basic biological mechanisms and the molecular bases of disease. In order to accomplish its mission, the MRC continues to invest in both state of the art equipment and trained personnel. The MRC houses a full range of equipment in its core laboratories that facilitate molecular genetic and biochemical studies at the sub-cellular and systems biology levels. In addition to providing technical services on a cost basis, the MRC personnel assist and instruct investigators in applying specialized tools of modern molecular biology to basic and clinical research. (MRC)
Protein and Proteome Characterization Facility
Currently there are four instruments available for protein identification. All of the necessary search engines and bioinformatics expertise for data analysis are provided by an established infrastructure through the Center for Biomedical Informatics.
Flow Cytometry Core
The flow cytometry facility is centrally located in the Molecular Sciences Building and equally accessible to all CTSI investigators located at UTHSC and the partner institutions. (FCC)
UTHSC Imaging Core and Integrated Microscopy Center at the University of Memphis
The imaging core includes four individual confocal microscopy suites distributed in different campus locations, two deconvolution microscopy suites, one scanning and two transmission electron microscopes, a computer-assisted light microscopic work station for quantitative 3-dimensional reconstructions and stereological cell counting, and a laser capture dissection microscope. Light and electron microscopes, including an environmental scanning electron microscope, several transmission electron microscopes and a freeze substitution unit are also available to iRISE investigators in the Integrated Microscopy Center at the University of Memphis. (IMC)
Viral Vector Core (VC)
The Viral Vector Core provides quality-controlled stocks of viral vectors as investigational tools for examining the molecular mechanisms of human disease and developing new therapeutic strategies for genetic disease and cancer based on gene transfer. (VC)
Drosophila Transgenic Core (DTC)
The DTC provides investigators with the ability to utilize the rapid genetic screening tools in Drosophila to quickly identify genetic pathways or individual genes related to diseases of interest. (Drosphilia Core)
Bioengineering and Biomaterials Testing Core (BBTC)
The BBTC provides translational researchers with expertise and state-of-the-art facilities for fabrication, robotic testing, biosensors, and biomaterials synthesis, characterization, and testing. (BBTC)
Center for Integrative and Translational Genomics (CITG)
This center has assembled five major core facilities in proteomics, transgenics, microarray analysis, computational biology, and gene discovery. Highlights include:
Unique experimental mouse populations: Novel murine models that more closely represent the complexity and admixture of human populations, including a population of over 100 isogenic lines of mice (the BXD population) that are now widely used by investigators at UTHSC, ORNL, Vanderbilt, and SJCRH.
Unique bioinformatics tools for translational research: GeneNetwork is a set of linked data sets and resources for systems genetics. Adaptation of GeneNetwork to human populations will add to its translational significance and serve as a model for future work.
Microbial Pathogenesis Research Program (MPRP)
The MPRP provides a platform to unite broad-based research programs in basic, translational and clinical research focused on pathogenesis, diagnosis, treatment and prevention of infectious diseases. The center features work on development of therapeutics, vaccines and new diagnostics. The repertoire of pathogens that are under investigation has expanded dramatically with the opening of one of 13 NIH-funded Regional Biocontainment Laboratories (RBL) on the UTHSC campus.
Drug Development and Discovery Core (DDDC)
The DDDC provides multidisciplinary assistance to efficiently transform new biomedical knowledge into novel medications or new pharmacotherapeutic treatment modalities. The DDDC is designed to comprehensively address the needs for resources, expertise and services throughout the entire drug development process, from target validation and drug discovery up to clinical development. This includes lead compound design and optimization, high throughout screening and biomarker identification, formulation design and drug product manufacturing, pharmacokinetic and metabolic profiling, toxicological screening, and bioanalytical assay development and validation, skills that until now have been scattered across campus departments and colleges. Thus, the DDDC provides an innovative and transformative one-stop access point for most services required for preclinical and early clinical development of new therapeutic products. The involved faculty and laboratories span seven academic departments, four colleges and three institutions, UTHSC, U of M and SJCRH. DDDC members have an established track record of successful collaborations in drug development activities. (DDD)
Tissue Services/Biorepository Core
This facility is located in the UT Department of Pathology and collects, processes, archives and distributes de-identified human samples for translational research investigators. (TSBC)
The UTHSC Department of Comparative Medicine (DCM) is responsible for the husbandry and veterinary care for all vertebrate animals maintained for research, teaching, or testing on the campus in four University-owned campus locations. Specialized housing areas for maintenance of animals used in biohazardous studies are also available. The Institutional Animal Care and Usage Committee (IACUC) reviews and approves all protocols for vertebrate animals used in research, teaching, or testing at the University of Tennessee Health Science Center. Specialized imaging and other equipment for small animals, including a 32-station Columbus Instruments CLAMS system for metabolic monitoring and EchoMRI for body composition analysis, are available to users. The Chair of UTHSC Department of Comparative Medicine, Dr. Timothy Mandrell, oversees the animal facilities (firstname.lastname@example.org).